Anaphylactic shock: mechanisms and treatment.

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Anaphylactic shock: mechanisms and treatment.

This paper reviews the mechanisms of anaphylactic shock in terms of the immunoglobulin and non-immunoglobulin triggering events, and the cellular events based on the rise in intracellular cyclic AMP and calcium that release preformed granule-associated mediators and the rapidly formed, newly synthesized mediators predominantly based on arachidonic acid metabolism. These primary mediators recrui...

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Anaphylactic shock: pathophysiology, recognition, and treatment.

Anaphylaxis is a systemic, type I hypersensitivity reaction that often has fatal consequences. Anaphylaxis has a variety of causes including foods, latex, drugs, and hymenoptera venom. Epinephrine given early is the most important intervention. Adjunctive treatments include fluid therapy, H (1) and H (2) histamine receptor antagonists, corticosteroids, and bronchodilators; however these do not ...

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Anaphylactic Shock

Anaphylactic shock is an unexpected, sudden and sometimes deadly event that attacks the patient in 75% of the cases without pre-existent history of allergy. In general, drugs, hymenopteric poisons and nutrients (according to the recent concept) are responsible. Beside the classical IgE-mediated anaphylactic shock there exists another anaphylactic shock, identical in its clinical picture and tre...

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Experiments are described which show that anaphylactic shock can be induced in animals sensitized with azoproteins by injecting them with azodyes containing the same azo components as the sensitizing antigen. The anaphylactic reactions are specific and occur with quantities of the dyes as small as fractions of milligrams.

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ژورنال

عنوان ژورنال: Emergency Medicine Journal

سال: 1995

ISSN: 1472-0205,1472-0213

DOI: 10.1136/emj.12.2.89